New research papers

• Prevalence of venous extension in malignant adrenal neoplasia: beyond primary tumors and identification of a novel imaging sign 28/02/2026
  CONCLUSION: Venous extension was less prevalent in metastatic adrenal lesions compared to ACCs. The edge sign may precede venous extension, especially in metastatic cases, indicating the nature of the lesion. These findings potentially may alter disease management, expediting the decision for surgery; however, prospective multicenter studies are needed to confirm their clinical impact.
  Lais P D M Melges
• Using Mendelian randomization to investigate etiologic heterogeneity across renal cell carcinoma subtypes 31/10/2025
  CONCLUSION: These results highlight the heterogeneous nature of RCC etiology and the importance of considering histologic subtypes in etiologic and genetic studies.
  Timothy D Winter
• Capivasertib plus abiraterone in PTEN-deficient metastatic hormone-sensitive prostate cancer: CAPItello-281 phase III study 21/10/2025
  CONCLUSIONS: Capivasertib plus abiraterone improves rPFS versus placebo plus abiraterone in PTEN-deficient mHSPC, on a background of ADT, with a 7.5-month improvement in median rPFS. AE profile was consistent with that of the individual agents. Patients with PTEN-deficient mHSPC benefit from dual blockade of the PI3K/AKT and AR pathways with capivasertib plus abiraterone.
  K Fizazi
• Reply to the Letter to the Editor: MRI-detected extranodal extension as a marker of prostate cancer aggressiveness 06/08/2025
  No abstract
  Aline Araújo Naves
• KLK5 and KLK7 drive cervical carcinoma via KLK14-dependent RhoA and NF-κB pathways 03/08/2025
  CONCLUSION: This study underscores the critical roles of serine proteases KLK5, KLK7, and KLK14 in cervical carcinogenesis, suggesting that these serine proteases are promising targets for the development of novel therapeutic strategies in cervical cancer.
  Gabriel Viliod Vieira