News from LTO
08/01/2021 – 2 FAPESP PhD fellowship open until 31-AGO
08/01/2021 – FAPESP Younger Investigator Award approved!
04/22/2021 – Chernobyl Trio paper published at Science!
04/10/2021 – Congrets Eliza for FAPESP grant
03/10/2021 – Congrets Lana for FAPESP grant
03/02/2021 – Welcome Letícia (Undergraduate Research Student)
01/24/2021 – BRAVE Novartis approved!
12/22/2020 – PRONON approved!
12/10/2020 – Aline’s work published at Sci Rep!
12/08/2020 – Marina’s IO review at Current Opinions published!
12/07/2020 – Welcome Bianca (Master Student)
11/06/2020 – Newton Advanced Fellowship Award approved
11/01/2020 – Welcome Sabrina (Staff Research)
10/30/2020 – ISR Grant for immunotherapy in RCC approved
10/20/2o2o – Congrats Guilherme for FAPESP grant
09/30/2020 – Molecular Oncology Workshop
09/01/2020 – Congrets Eliza for PIBIC/CNPq grant
08/01/2020 – Congrets Jamile for FAPESP grant
25/06/2020 – Welcome Camila, Carol, Cecília, and Lucas (Master Students)
10/06/2020 – Welcome Marina (PhD Student)
15/11/2019 – Welcome Eliza (Undergraduate Research Student)
21/10/2019 – Welcome Guilherme (Master Student)
15/09/2019 – Welcome Lana (Undergraduate Research Student)
12/08/2019 – Welcome Aline (Postdoc)
02/07/2019 – Welcome Jamile (Undergraduate Research Student)
- Telomeres length and Wnt/β-catenin pathway in adamantinomatous craniopharyngiomas 18/05/2022CONCLUSIONS: CTNNB1 mutations are more frequent in children and adolescents and appear to associate with progressive disease. CTNNB1-mutated aCPs have shorter telomeres, demonstrating a relationship between the Wnt/β-catenin pathway and telomere biology in the pathogenesis of aCPs.Jose Italo Soares Mota
- Extracellular Vesicles and Interleukins: Novel Frontiers in Diagnostic and Therapeutic for Cancer 07/04/2022Tumor cells present many strategies for survival and dissemination in the tumor environment. Extracellular vesicles are a vital pathway used in crosstalk between tumor and non-malignant cells. They carry different types of molecules that, when internalized by target cells, can activate signaling pathways and molecular processes that will promote and disseminate neoplastic cells. Proteins, nucleic […]Aline G Souza
- Immune Checkpoint Inhibitors in Tumors Harboring Homologous Recombination Deficiency: Challenges in Attaining Efficacy 25/02/2022Cancer cells harbor genomic instability due to accumulated DNA damage, one of the cancer hallmarks. At least five major DNA Damage Repair (DDR) pathways are recognized to repair DNA damages during different stages of the cell cycle, comprehending base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR), homologous recombination (HR), and non-homologous end […]Saulo Brito Silva
- Associação Brasileira de Hematologia, Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. Review article: Cell therapy in solid tumors 19/11/2021The use of immunotherapy in cancer treatment over the past decade has resulted in significant advances and improvements in cancer patients survival with the use of checkpoint inhibitors. Nevertheless, only a fraction of solid tumors responds to this immunotherapy modality. Another modality of immunotherapy consists of employing cell-based therapy as an adoptive therapeutic modality. That […]Mirella Nardo
- Altered regulation of DPF3, a member of the SWI/SNF complexes, underlies the 14q24 renal cancer susceptibility locus 14/08/2021Our study investigated the underlying mechanism for the 14q24 renal cell carcinoma (RCC) susceptibility risk locus identified by a genome-wide association study (GWAS). The sentinel single-nucleotide polymorphism (SNP), rs4903064, at 14q24 confers an allele-specific effect on expression of the double PHD fingers 3 (DPF3) of the BAF SWI/SNF complex as assessed by massively parallel reporter […]Leandro M Colli